Neurons are polarized cells possessing axonal and dendritic processes with distinct morphologies, cytoskeletal architectures and signaling properties. Polarity is established during neuronal differentiation and is essential for the assembly and function of the nervous system. The trajectories of axons and dendrites are shaped by growth cones at their tips responding to guidance cues in their environment. We are interested in understanding the cellular and molecular mechanisms that polarize neurons and pattern their axons and dendrites.
