The lab focuses on studying new skeletal dysplasias, new forms of epilepsy and chromatin remodeling disorders. We identify new disease-causing genes, understanding the pathological basis of disease, and try to improve the management of children affected by these conditions.
The tasks of the trainees will be to analyze exome and genome data to identify causative mutations. Then, the mutations will be introduced in expression vectors by standard molecular biology approaches, or in cell lines (such as induced pluripotent cell lines) by the CRISPR/Cas9 approach. In vitro, the effect of the mutations on the gene’s pathway will be assessed by a combination of analysis of RNA, protein and cell studies. These techniques include but are not limited to RNA-seq, ChIP-seq, ATAC-seq, and flow cytometry. In addition, the mutations may be introduced in in mouse lines also by the CRISPR/Cas9 approach, to eventually phenotype the mice.
Applicants should have extensive molecular biology experience in research labs, and provide simply a CV and University transcripts.
Linguistic Policy The Université de Montréal uses French for language of instruction. To renew its teaching faculty, the University is intensively recruiting the world's best specialists. In accordance with the institution's language policy , the Université de Montréal provides support for newly recruited faculty to attain proficiency in French. Immigration Requirements and Employment Equity Program In compliance with Canadian immigration requirements, priority shall be given to Canadian citizens and permanent residents. The Université de Montréal upholds the principles of employment equity and welcomes applications from women, ethnic and visible minorities, aboriginals and people with disabilities. Privilege of candidates' confidentiality The nomination process in effect at the University of Montreal permits that all professors of the department be able to examine the candidates' dossiers. Any person preferring that their candidature remain confidential until the establishment of the shortlist (candidates selected for an interview) should mention this in their presentation letter. Program of equal opportunity hiring The University of Montreal subscribes in principle to equal opportunity hiring and invites women, members of visible minorities, members of ethnic minorities, individuals with handicaps and native people to apply. We invite all applicants to fill out the form for equal opportunity hiring, available at the following address : http://www.drh.umontreal.ca/documents/bpe/bpe_paee/formulaire_PAEE_bpe.pdf, and to include it with their application. We assure you that all information will be kept confidential and will only be used for statistical purposes regarding equal access, conforming with article 18,1 of the Charter of rights and freedom of the individual.
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