Dr. Rodriguez’s research programs focus on the understanding of the cellular and molecular mechanisms that control leukocyte dysfunction in tumors, with a focus on T cells and myeloid cells. The long-term goal of his research is to develop new therapeutic strategies that restore protective immunity in cancer, leading to long lasting anti-tumor effector T cell immunity. Dr. Rodriguez current research programs are summarized as following: 1. To determine the role of central pathways associated with cellular stress in the tumor microenvironment as primary regulators of the immune suppressive activity found in tumor-related myeloid cells and T cells. 2. To elucidate the relevance of the inhibition of Notch1 signaling in the T cell dysfunction occurring in solid tumors and as a limitation of T cell-based immunotherapy. 3. To understand the central metabolic circuits that control the accumulation and dysfunction of myeloid and T cell subsets in the tumor milieu. These strategies are explored throrugh a combination of in vitro approaches using primary murine and human cells, as well as live animal modeling to dissect the pathways underlying the impaired immune responses occurring in cancer.
This position focuses on the understanding of the effects of signaling molecules related with endoplasmic reticulum (ER) stress in the immune dysfunction occurring in tumor-bearing hosts and patients with cancer.
A key component of this effort is the identification of the mechanisms by which tumor-associated stress modulates the function and survival of T cells and myeloid subsets in individuals with cancer, enabling the development of novel approaches to overcome immune suppression in cancer.
The Ideal Candidate:
We are especially interested in candidates who have a strong background in myeloid cell and T cell-linked immunology, molecular biology, imaging approaches, and tumor animal models.
Experience with multi-color flow cytometry, fixed and live cell confocal microscopy, gene silencing and overexpression technologies in primary cells, viral vector generation, and in vivo models of cancer are preferred.
Post-doctoral applicants with strong track record of high quality research in immunology and excellent publication productivity are desirable.
Candidates are expected to participate in multiple academical activities, including the conception and development of experimental projects, troubleshooting of experimental approaches, scientific interaction and mentoring to junior members in the group, and writing and submission of manuscripts and grants.
Participation in academic presentations in the group and immunology program.
Credentials and Qualifications:
MD or PhD in Immunology or highly related areas.
Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Paulo C. Rodriguez, PhD at Paulo.Rodriguez@Moffitt.org.
Equal Employment Opportunity
Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence.
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