Assistant/Associate/Full Project Scientist - Molecular Genetics - Innovative Genomics Institute
The Innovative Genomics Institute (IGI) is a multidisciplinary research institution focused on genome engineering and potential applications in agriculture, microbiology and biomedicine. It is a joint venture between UC Berkeley and UC San Francisco, with the administrative operations located on the Berkeley campus. This position is located at the UC Berkeley campus.
The IGI is presently seeking highly motivated Project Scientists to conduct research towards clinical translation of genetic therapies for inherited disorders of hematopoiesis such as sickle cell disease (SCD) and primary immunodeficiencies (PID). This work will be performed as part of a team effort within the Center for Translational Genomics (CTG) at UC Berkeley. Specific goals will be the evaluation of new genome editing enzymes for SCD/PID therapy, the improvement of existing therapeutic approaches, and the assessment of ex vivo genome editing outcomes in human hematopoietic stem/progenitor cells (HSPCs) and/or T cells, evaluation of the impacts of procedures on the edited HSPCs/T cells, and communication with organizations responsible for manufacture or regulation of therapeutics. Our ideal candidates are those with the demonstrated ability to effectively communicate, are efficient and open in collaboration, and those who enjoy engaging with a diverse group of researchers. The ideal candidates will also be innovative and able to synergize various ideas and approaches, while exercising sound judgment to evaluate and take acceptable risks. Occasional travel will be required.
The Project Scientists will also collaborate with IGI investigators at UCB, UCSF, UCLA and other IGI-affiliated universities in the use of genome editing to treat hemoglobinopathies such as SCD and/or primary immunodeficiencies.
Basic Qualifications (at the time of application):
Ph.D. or equivalent international degree
Additional Qualifications (by start date):
The candidates must have a minimum of 2 years of post-doctoral and/or industry experience
- Degree in related field such as Molecular Genetics, Cell Biology, Biochemistry, Bioengineering, or related discipline
- Experience with genetic manipulation of mammalian cells.
- Experience with the development and improvement of genome editing tools.
- Experience with the development of genetic and/or cell-based therapies.
- Experience with GMP manufacture of therapeutics.
- Experience interacting with the FDA (e.g., IND submission).
- Experience with ex vivo delivery of genome editing reagents.
- Experience with preclinical transplantation models (e.g., humanized mice).
- Experience culturing primary cells of the hematopoietic system.
- Experience culturing HSPCs, including assessment of hematopoiesis (e.g. CFU assays).
This position reports directly to Professor Fyodor Urnov. The initial appointment will be at 100% time for one year with the possibility of extension based on satisfactory performance and availability of funding.
Salary and Benefits:
These positions provide full benefits.
Salary will be commensurate with qualifications and experience.
These positions are represented by UAW Local 5810 and covered by a collective bargaining agreement.
Specific questions regarding the recruitment can be directed to Professor Urnov, at firstname.lastname@example.org
This recruitment will remain open until filled.
All letters will be treated as confidential per University of California policy and California state law. Please refer potential referees, including when letters are provided via a third party (i.e., dossier service or career center), to the UC Berkeley statement of confidentiality (http://apo.berkeley.edu/evalltr.html
) prior to submitting their letters.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct
The department is interested in candidates who will contribute to diversity and equal opportunity in higher education through their work.
To apply, visit https://aprecruit.berkeley.edu/JPF02791