The laboratory of Dr. Weixing Zhao in the Department of Biochemistry and Structural Biology (BSB) and Greehey Children’s Cancer Research Institute (GCCRI) at UT Health San Antonio is seeking postdoctoral scientists to investigate the BRCA1/2 (Breast Cancer Susceptibility Gene 1 and 2) tumor suppressor network and the molecular mechanisms underlying its pathogenic mutations.
Dr. Zhao has developed class-leading expertise in the expression and purification of very large DNA repair proteins and multi-subunit DNA repair protein complexes, BRCA1, BRCA2 and their complexes in particular, for a detailed mechanistic workup. With these, Dr. Zhao has made important discoveries concerning the roles that the tumor suppressor complexes BRCA1-BARD1 and BRCA2-DSS1 fulfill in the homology-directed repair of damaged chromosomes (Zhao et al., Mol Cell, 2015 & Zhao et al., Nature, 2017). Research projects of the laboratory will be built upon those important breakthroughs and findings to further define the molecular mechanisms how the BRCA complexes cooperate together in DNA repair by using a variety of structural, biochemical, molecular biological, and biophysical techniques and cell biology systems. Furthermore, we will investigate the BRCA1-BARD1 tumor suppressor network, with a major emphasis on its ubiquitin E3 ligase activity, and how mutations in BRCA1 and BARD1 lead to cell transformation and cancers. Information garnered from these endeavors will help improve cancer risk assessment and identify critical targets for the development of novel cancer therapeutics for patients with mutations of BRCA genes.
UT Health San Antonio, comprised of Medical, Graduate, Dental, Nursing and Health Profession schools, is home to the Nathan Shock Center for Aging, an NCI-designated cancer center and NIH Clinical Translational Science Award and the Center for Neuroscience. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the art facilities and outstanding core laboratories including optical imaging, macromolecular Interactions, mass spectrometry, single-cell processing, biomolecular NMR and genomic analysis. Moreover, San Antonio is the 7th largest city in the U.S., with a historical downtown, diverse entertainment and restaurants on the Riverwalk, a vibrant economy, affordable housing and easy access to the scenic Texas Hill Country, with its many recreational opportunities.
Applicants should a recent Ph.D. (or expect to receive a doctoral degree soon), possess excellent experimental and communication skills, and demonstrate solid training in molecular and cellular biology, biochemistry and biophysics with scientific publications. Previous research experience in DNA repair and cancer biology is preferred but not required. In addition to competitive salaries and comprehensive benefits, the successful candidates will be provided with strong support for developing an independent research career after postdoctoral training.
Please send (1) a cover letter describing your previous training, research accomplishments and future research interests, (2) your curriculum vitae, and (3) contact information of three referees to Dr. Weixing Zhao at firstname.lastname@example.org.