Drs. Inna Smalley and Kenneth Tsai are recruiting a postdoctoral researcher interested in developing novel spatial transcriptomic and metabolomic techniques for the study of melanoma metastasis and immunotherapy responses of aggressive skin cancers. The postdoctoral researcher will undertake two projects describe below:
Project 1: Studying the spatial distribution, functional status, and cellular composition of the tumor microenvironment as it relates to immunotherapy response in melanoma, cutaneous squamous cell carcinoma, and Merkel cell carcinoma. The goal is to identify drivers of therapeutic response and to ultimately derive novel targets to address immunotherapy resistance.
Project 2: Studying the role of metabolic heterogeneity and cross-talk in melanoma CNS metastases and drug resistance. This project will incorporate both basic and translational research, but overall aim to transform clinical care of late-stage melanoma patients.
Candidates will collaborate closely with a postdoctoral fellow in the Department of Bioinformatics and Biostatistics to develop innovative analysis platforms for spatial transcriptomic and metabolomic techniques for their work. They will also interact with a team of immunologists, tumor biologists, mathematical modeling experts and clinicians at Moffitt Cancer Center (Tampa, FL) to conduct research in a highly collaborative environment. Ideal candidates have demonstrated expertise in signal transduction, metabolism, drug resistance, metastasis or single-cell analysis studies.
Studying the functionality of tumor heterogeneity, including metabolic symbiosis
Improving our understanding of interactions between the tumor and the TME
Developing cutting edge techniques for spatial RNAseq and metabolomics
In addition to the research, the position will have a focus on career development including grant writing, scientific writing/presentation, mentorship of junior members of the lab, networking, and building collaborations.
Co-mentorship by two NCI-funded investigators in a collaborative environment as part of a unique multidisciplinary T32 supported training program bridging molecular biology and bioinformatics.
Working with patient specimens (acquisition, processing, preparation for analysis, biochemical screening), establishing and maintaining tumor cell cultures, cellular signaling and phenotypic assays, establishing in vivo models, metabolic assays, and proteomic analysis.
Providing intellectual input on steering the project
Developing novel technical approaches
Mentoring graduate students and technicians
Composing manuscripts and postdoctoral fellowships, assisting with grant applications
Credentials and qualifications:
PhD in Cancer Biology, Molecular Biology, or a related field (required)
Strong written and oral communication skills and the ability to work independently and with collaborators.
Applicants must be U.S. Citizens or U.S. Legal Permanent Residents for this opportunity.
How to apply
Candidates should e-mail the following documents to firstname.lastname@example.org and email@example.com
1) A cover letter that describes their motivation to pursue this position, why they would be the perfect fit for these projects and summarizes past research accomplishments. They should also include a summary of what expectations/goals they have for this fellowship.
2) A current CV with recent publications and contact information for three references.
Equal Employment Opportunity
Moffitt is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. Moffitt seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence.
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