Control of cell emigration in development and cancer:
from single cell to integrated in vivo level.
Short Description of the PhD thesis project:
Cell emigration is an essential event to shape embryos during development, and the initial step for cancer metastasis in adults. The molecular mechanisms involved in the acquisition of cell motility, and cell ability to leave its epithelium of origin, are conserved in evolution and between embryos and adults: they involve a group of transcription factors which control cell-cell adhesion and cell invasiveness. These factors are themselves tightly regulated in embryos. Using the model of neural crest cells in embryos, one of the best understood models for cell emigration, this Ph. D. project will explore the mechanisms that control cell migrations at the single cell level, and integrate them within the in vivo context. This highly interdisciplinary project takes advantage of the intense interactions between two teams: The Monsoro-Burq team at Institut Curie (https://science.institut-curie.org/research/biology-chemistry-of-radiations-cell-signaling-and-cancer-axis/umr-3347-normal-and-pathological-signaling/team-monsoro-burq/ ) focused on understanding the gene regulatory network controlling neural crest formation, and the Peshkin team, at Harvard Medical School, USA, focused on developing mathematical tools applied to "omics" dataset analysis such as single cells technologies transcriptomics and epigenomics. Based primarily in Institut Curie on the Science Campus of Orsay in the south of Paris, the candidate will spend significant research time in Peshkin team.
For detailed description, see website: https://ic3iphd.curie.fr/project_detail.php?action=view&id=41
enquiries to: anne-helene.monsoro-burqcurie.fr
PhD applicant's profile:
International applicants (see Eligibility criteria) should have a strong motivation to explore cell biological phenomena in an in vivo context, and should show solid capacity for independent and creative thinking, as well as enjoy team work. Background in cell and molecular biology is strongly recommended. Bachelor level knowledge in biostatistics is appreciated. Background in developmental biology is a plus but not compulsory. The project highly relies on the preparation and analysis of large datasets and live imaging techniques, for which the applicant should have either experience or a strong motivation to learn.
Call description: https://training.institut-curie.org/article/current-call-for-applications
Application website: https://ic3iphd.curie.fr/application/login.php.
• To hold a Master’s degree by September 2019, or an equivalent university degree (five-year duration),
• To have obtained their Master's degree no later than 2 years ago,
• Not to have studied, worked or lived in France for more than 12 months during the three years prior to the end of the call for applications.
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