Staff Research Associate 2, Center for Translational Genomics (9612C) 23394
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The Innovative Genomics Institute (IGI) is a non-profit, academic research organization formed through the partnership of UC Berkeley and UC San Francisco, and located on the UC Berkeley campus. A key focus of the IGI is accelerating translation of CRISPR-based approaches to address real-world problems in human health, agriculture, and climate.
The IGI is committed to hiring and developing staff who want to work in a high performing culture that supports the outstanding work of our faculty and students. The IGI is interested in candidates who will contribute to our commitment to excellence, diversity, and inclusion in academia. The IGI is also interested in individuals who may have had non-traditional career paths, taken time off for family/personal reasons, or excelled in careers outside academia.
The IGI is presently seeking highly motivated Staff Research Associates (SRAs) to conduct research towards clinical translation of CRISPR-based therapies for neurological disorders such as Alzheimer's and Huntington's Disease. This work will be performed as part of a team effort within the Center for Translational Genomics (CTG) at UC Berkeley. In this role, the candidate will work with an internal supervisor and colleagues to support CTG research activities and objectives. Specific goals will be leading mammalian cell culture efforts and evaluating new CRISPR-based modalities for treating neurodegeneration using ex vivo, pluripotent stem cell derived models. The Staff Research Associates will closely collaborate with IGI investigators at UC Berkeley and UCSF as part of a comprehensive program to design and derisk novel CRISPR-based experimental therapeutics.
Application Review Date
The First Review Date for this job is: 9/16/2021
The Staff Research Associate (SRA) will lead workstreams involving a variety of techniques in the field of molecular biology, notably the establishment of mammalian cell cultures, and the implementation and analysis of CRISPR screenings. The SRA works under the general supervision of the facility manager and offers guidance and insight to other SRA and student workers. The SRA will need to possess excellent oral and written communication skills, a team focused mentality, and the ability to work independently and troubleshoot their own experiments. Advanced troubleshooting of experiments experience is preferred. The SRA will provide support to maintain, operate and quality control the laboratory instruments. The SRA must adhere to all campus and Environmental Health and Safety (EH&S) policies/procedures.
Key Responsibilities include:
- Establish and maintain cell cultures for hESC, HiPSC, primary neurons and cell neuronal stem cell/progenitor cell, transformed cells and mixed cell culture lines.
- Provide high-quality cells to internal and external scientists working on genome editing and related projects.
- Perform a variety of specialized laboratory procedures in the field of genome editing.
- Work with university service cores to measure genome editing by next-generation sequencing, flow cytometry, and other available assays.
- Collaborate with research staff on troubleshooting culture and genome editing methods.
- Modify, vary or adapt standard procedures to meet the needs of genome editing projects, and improve existing tests.
- Quantitate and evaluate genome editing screening results in mammalian cells.
- Maintain accurate records of research in laboratory notebooks, draft protocols, and present in small group meetings with IGI and CTG staff.
- Perform standard instrumentation and facility maintenance (e.g., instrument calibrations, routine maintenance, maintaining laboratory spaces).
- B.S. or equivalent international degree in the Biological Sciences, such as Molecular Genetics, Cell Biology, Biochemistry, Bioengineering, or a related discipline or equivalent combination of education and experience.
- Extensive hands-on mammalian cell culture experience is required.
- Experience setting-up and troubleshooting mammalian cell culture systems is required.
- Extensive hands-on molecular biology experience is required.
- Ability to keep proper records.
- Ability to be cooperative and team-oriented.
- Strong organizational skills and attention to detail.
- Strong ability to efficiently work in a diverse group.
- Strong ability to maintain external collaborations with researchers.
- Excellent oral and written communication skills.
- Hands-on experience with primary neuron cultures.
- Hands-on experience with stem and progenitor cell cultures.
- Experience with CRISPR-based genetic editing of mammalian cells.
- Experience with multi-color flow cytometry.
Salary & Benefits
Salary commensurate with experience. For information on the comprehensive benefits package offered by the University visit:
How to Apply
Please submit your cover letter and resume as a single attachment when applying.
Equal Employment Opportunity
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see:
For the complete University of California nondiscrimination and affirmative action policy see:
To apply, visit https://careerspub.universityofcalifornia.edu/psp/ucb/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&Action=U&FOCUS=Applicant&SiteId=21&JobOpeningId=23394&PostingSeq=1