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Job ID: 172935

Post-doctoral Fellow
University of Michigan, Ann Arbor


Date Posted Nov. 19, 2021
Title Post-doctoral Fellow
University University of Michigan, Ann Arbor
Ann Arbor, MI, United States
Department Molecular and Integrative Physiology
Application Deadline Open until Filled
Position Start Date Available immediately
 
 
  • Post-Doc
  • Biomedical Sciences
    Biology - Computational
    Anatomy/Physiology
 
 

Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale Modeling

Daniel Beard, Johnathan Tune, and Alberto Figueroa are looking to hire a postdoc to work in a project which seeks to investigate mechanisms of coronary blood flow regulation using animal models and computational modeling. Please see details below.

  • Interested in learning about the complex mechanisms ruling coronary blood flow auto-regulation in health and disease?
  • Would you like to work in a multi-disciplinary team, with experts in coronary physiology, animal models, and computational modeling?
  • If so, we are looking for a talented post-doc to help us with this challenging and exciting project.
  • Suitable candidates will have a PhD in applied math, biomedical or mechanical engineering, or quantitative physiology, and have experience in modeling blood flow.
  • If interested, email your curriculum vitae and at least two references to figueroc@med.umich.edu

Abstract:
The most prominent theories to explain coronary autoregulatory behavior are the local metabolic and myogenic hypotheses. However, given that these pathways share common end-effector pathways and microvascular responses, differ transmurally across layers of the myocardium, and are influenced by structural and contractile properties of the myocardium, our knowledge remains rather phenomenological.
The primary goal of this proposal is to address this deficit through computational and experimental studies to build, test, and refine competing hypotheses for the metabolic mechanism in the context of a multi-scale model of coronary flow regulation. Our approach builds on our recent efforts with constrained mixture theory models and in vivo assessment of coronary pressure at zero-flow (Pzf), an index of underlying myogenic tone. Applying this experimental and modeling framework to test and refine hypotheses regarding pathologically over-active myogenic response in coronary microvascular dysfunction associated with obesity will provide further insight into short- vs. long-term impact of microvascular adaptions in health and disease.


  • The University of Michigan, as an equal opportunity/affirmative action employer, complies with all applicable federal and state laws regarding nondiscrimination and affirmative action. The University of Michigan is committed to a policy of equal opportunity for all persons and does not discriminate on the basis of race, color, national origin, age, marital status, sex, sexual orientation, gender identity, gender expression, disability, religion, height, weight, or veteran status in employment, educational programs and activities, and admissions. Inquiries or complaints may be addressed to the Senior Director for Institutional Equity, and Title IX/Section 504/ADA Coordinator, Office for Institutional Equity, 2072 Administrative Services Building, Ann Arbor, Michigan 48109-1432, 734-763-0235, TTY 734-647-1388, institutional.equity@umich.edu. For other University of Michigan information call 734-764-1817.


 
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Contact Information

 
  • C. Alberto Figueroa
    Biomedical Engineering
    University of Michigan, Ann Arbor
    2800 Plymouth Rd
    NCRC Building 20 - 211W
    Ann Arbor, MI 48109
  •  
  • figueroc@med.umich.edu

 

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