1. To understand different biological aspects of human infertility, 2. The development of a transgenic non-human primate model for genetic diseases such as Huntington`s and Parkinson`s, etc., 3. The biology of the differentiation control of rodent and non-human primate embryonic stem (ES) cells, and 4. The applications of ES cells in treating neurodegenerative diseases such as Parkinson`s.