Our research focuses on DNA repair mechanisms and how aberrant repair results in increased genome instability and a predisposition to cancer. The projects in the lab focus on the homologous recombination (HR) pathway of DNA double strand break repair in mammalian cells. HR factors are not only required for repair of double strand breaks, but play critical roles in protecting stalled replication forks. Using a combination of genetic, cellular and biochemical approaches, our lab focuses on generating targeted mutations in HR factors to gain mechanistic insight into the role of HR proteins in replication and repair.
