Throughout their lifetimes, cells are constantly bombarded by an ever-changing environment. They integrate these environmental changes with information about themselves to make important decisions of cell fate. Mistakes in these processes can lead to developmental defects or cancer. Research in my laboratory is interested in understanding how cells integrate information about themselves and their environments to make the correct cell fate decision. Using the budding yeast S. cerevisiae as an experimental model, we are currently focusing on the roles of post-translational histone modifications in controlling yeast cell fates. To understand this question, we regularly employ genetic, molecular, biochemical, and genomic approaches.
