Delineate the interplay between V-ATPase and the Pma1p plasma membrane proton pump during cytosolic pH homeostasis in C. albicans and determine the relative contribution of cytosolic pH to fungal virulence.
Identify novel players involved in V-ATPase pathways in C. albicans; these may serve as possible anti-fungal drug targets that can be manipulated to treat life-threatening, drug-resistant fungal infections.