Who's Who in
Sciences Academia

    Choon Kim

  • Research Assistant Professor
  • Choon Kim
  •  
  • Department of Chemistry and Biochemistry
  • http://www.science.nd.edu/chemistry/chemistry.html
  • University of Notre Dame
  •  
  • 251 Nieuwland Science Hall
    Notre Dame, Indiana 46556-5670
  •  
  •  
  • Contact by e-mail?
  •  
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a nefarious human pathogen. It causes both hospital-acquired (HA-MRSA) and community-acquired (CA-MRSA) infections. MRSA kills approximately 11,000 individuals annually in the United States alone. About 80% of MRSA bacteria harbor a bla operon that consists of two regulatory genes, blaR1 and blaI, and a structural gene blaZ encoding a class A β-lactamase (BlaZ), a resistant determinant for β-lactam antibiotics. Dr. Kim recently identified for the first time that the staphylococcal BlaZ exists in two forms, one phosphorylated and another not phosphorylated. A remarkable feature of this discovery is that when the protein is phosphorylated, it is sequestered exclusively to the bacterial membrane by lipidation, whereas the non-phosphorylated form is excreted to the milieu. An intriguing observation pointed to the potential involvement of BlaZ in staphylococcal virulence. When the blaZ was removed from MRSA, it exhibited an increase of opsonophagocytic killing by neutrophil cells as well as a decrease in deposition of the complementary protein C3b.

    Dr. Kim’s research focuses on the elucidation of the pathways that inhibition of phosphorylation of BlaZ would target for release from the S. aureus surface, leading to its loss as a virulence factor for the bacterium. We expect that our identification of the kinase(s) phosphorylating BlaZ will make it a target for inhibition that converts virulent strains to avirulent ones.
  •  

  • Start A New Search

    If you are a faculty member and are not presently included in our Who's Who in Academia, you may submit a request to be added.

    If you are currently included in our database and have previously established an account, you can update any of the information shown in your record.