The Hunsicker-Wang lab explores the relationship between protein structure and function. Researchers study metalloproteins from a unique bacterium, Thermus thermophilus. These proteins have high stability and make them amenable for structural studies using X-ray crystallography. The proteins that are studied are involved directly or indirectly in the respiration process. The lab uses a combination of mutagenesis, chemical modification, and spectroscopic and structural tools to study these proteins.