Dictyostelium discoideum
Neuronal ceroid lipofuscinosis (Batten disease)
Extracellular matrix
Signal transduction
Cell motility and adhesion
Calcium and calmodulin
Cyclin-dependent kinases
My lab uses the social amoeba Dictyostelium discoideum as a model system for studying the functions of proteins linked to human disease and the structure and function of the extracellular matrix (ECM). Current research is focused on revealing the cellular mechanisms underlying neuronal ceroid lipofuscinosis (NCL, also known as Batten disease), and identifying proteins within the ECM that modulate cell motility and differentiation during Dictyostelium development.