Jenny's research focusses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes. Early work made classic contributions to our understanding of the molecular mechanism of X chromosome inactivation and the control of DNA synthesis in mammalian cells.