1) the application of radiogenic isotope systems (Lu-Hf, Sm-Nd, U-Pb, Rb-Sr, Ar-Ar) to the study of metamorphic mineral reactions and tectonic events in the context of the P-T-t evolution of high-pressure terranes; 2) combining large-scale as well as detailed field mapping, in conjunction with structural and petrologic observations at mountain to microscopic scales, to deduce the timing and nature of mountain building and mountain collapsing events; 3) application of isotope tracers and trace elements to the study of mantle and crustal evolution; 4) isotope geochemistry of orogenic magmas; and 5) refinement of mass spectrometry and sample preparation procedures used for isotope ratio and isotope dilution measurements by TIMS and MC-ICP-MS.