GTPases of the Ras Family; Protein Interactions; Protein X-ray Crystallography; Solvent Mapping of Protein Surfaces; Structure Based Ligand Discovery
Research in the Mattos Lab focuses on understanding the rules that govern the recognition, assembly and function of macromolecular complexes. It is clear that macromolecular interactions are central to the proper functioning, regulation and specificity of any cellular process, for example, signaling, transport, and replication. We are particularly interested in the protein-protein interactions that allow these assemblies to form in a specific manner. We are also interested in how small ligands are able to mediate or interfere with these interactions.
