The long-term goal of my laboratory is to understand the mechanisms of neuronal interactions in health and disease. We employ a multi-disciplinary approach that synthesizes in vitro neurophysiology, imaging, molecular biology, immunohistochemistry, and computational neuroscience. Using these techniques we are trying to understand alterations in single cells and neural networks that lead to epileptic seizures, abnormal excitability in Alzheimer's disease, or occur following a traumatic brain injury