1.SCID mice model to study the interactions among peripheral blood monocytes, human periprosthetic tissue and bone tissue that lead to wear debris-associated loosening following total joint replacement.
2.Combination gene therapy of anti-inflammation and counter-osteolysis for rheumatoid arthritis using a mouse collagen-induced arthritis model.
3. A long-term murine model of prosthetic knee joint for implant stability, debris-associated bone resorption and potential gene therapy.
4.Soluble VEGF receptor gene therapy in controlling growth and metastasis of osteosarcoma in a novel mouse model.
5.Engineered bone graft substitutes for large bone defect. The study uses in intro and in vivo approaches to explore the type, composition, porosity, and biocompatibility of biomaterial scaffolds with the bedding and growth of osteo- and endothelial progenitor cells directional inducted from bone marrow stromal cells.
6.Minocyclin-associated bone discoloration and its molecular mechanism
