Applying high throughput sequencing to cancer and human genetic diseases
1) Determine the genetic events that lead to treatment resistance, relapse and metastasis in common human cancers such as lymphoma
2) Develop sensitive assays for detecting the presence of tumour cells and key driver mutations in the bloodstream of patients
3) Identify commonalities and differences between common canine cancers and their human counterparts
4) Develop improved methods for detecting mutations in massively parallel sequencing data and integrating distinct mutation types to aid in identifying driver mutations