Infection associated cancers are increasing at an alarming rate. Human papillomavirus (HPV) infection is estimated to cause one-third of the 1.5 million cancers attributed to viruses. The HPV related cancers include cervical cancer, head and neck squamous carcinoma, and anal cancer. Our long-term goal is to understand the basic processes that are necessary to establish HPV infection. Understanding the process of initial viral entry and trafficking can result in novel approaches to decrease infection and lessen the burden of HPV related cancers