Broadly, my research interests are in the area of molecular genetic mechanisms underlying human brain disorders. During my PhD at the University of Illinois in Chicago, I studied the role of DNA replication in trinucleotide repeat expansions, a form of genomic instability responsible for multiple neurodegenerative and neurodevelopmental disorders. Trinucleotide repeats, such as (CGG)n, (GAA)n, (CAG)n, have the common property to increase in length when transmitted from parents to offspring, a phenomenon mediated by DNA replication and recombination defects
