Our research program is built on the premise that chemical separation is driven by physical field and chemical equilibrium. With the insights into how molecules are separated and detected in capillary columns, we wish to design novel instrument that can provide even more separation power for chemical analysis and purification. Interestingly, the newly designed instrument comes with newly created problems to be solved, and new phenomena to be explained. Our group enjoys meeting these challenges with many wonderful tools available to us, including what we have learned in physics, mathematics, computer science, and most importantly