In the Sohl lab, we are interested in probing mechanistic questions at the intersection of biochemistry and human disease. We use kinetic, structural, and cellular tools to address how altered enzyme activity impacts human health. In particular, we are interested in exploring the catalytic, structural and functional consequences of enzyme mutations implicated in diseases such as cancer. By understanding these molecular mechanisms of dysfunction, we can illuminate structure-function relationships, identify affected downstream pathways and ultimately develop platforms for targeted therapy
