William Barletta maintains a broad range of professional research activities that include free electron laser physics for ultra-fast synchrotron radiation science, the design of colliders and high intensity linacs and cyclotrons for high energy and nuclear physics, ion beam technology for nanofabrication of integrated circuits, and compact plasma-based neutron and gamma sources for medicine, research and security applications. In addition he has a strong secondary research interests in international legal and policy aspects of cyber-security and cyber-conflict and in strategic management of research institutions.