The Bimolecular Systems Laboratory develops and applies computational/mathematical methods, and high throughput experimental methods, to analyze changes in gene and protein expression profiles of cells in response to various endogenous and exogenous signals. In collaboration with the Fraunhofer Center for Manufacturing Innovation, and the Departments of Chemistry and Physics, we are developing and applying new DNA and peptide microarray technologies for fingerprinting the complete molecular state of a cell. Examples include the response to ligands (drugs, toxins, hormones etc), and changes that occur as normal cells mature, differentiate, progress toward disease. The long range goal is to relate expression patterns to pathways, pathways to networks and networks to function.
