Maloney has a longstanding interest in the functioning of the immune system, initially in the fields of immunoparasitology and bacterial pathogenesis, and more recently in the area of B cell development. The glycosphingolipid Gb3 (CD77) serves as receptor for the Shiga toxins produced by "Escherichia coli and Shigella. However, the normal cellular functions of Gb3 are less well defined.
Dr. Maloney's research focuses on identifying human proteins that interact with Gb3 and characterizing the cellular functions of Gb3 including its role in apoptosis pathways, cell adhesion and alpha-interferon signal transduction in Blymphocytes and Burkitt lymphoma cells.