The research in our laboratory aims to use molecular approaches to investigate key questions at the interface of virology, pathogenesis, and the human cellular immune response to human immunodeficiency virus (HIV) infection. Current studies focus on understanding the impact of viral immune escape mutations on cytotoxic T lymphocyte (CTL) recognition and on HIV protein function, measuring the ability of T cell receptors (TCR) to recognize and kill HIV-infected cells, and assessing the relevance of viral tropism and cellular compartments on disease progression
