Alzheimer’s disease is partly characterized by the intracellular deposition of Neurofibrillary tangles that are made up of hyperphosphorylated and proteolytically cleaved tau protein. In my lab, we study the effect of tau truncation, by calpain, on polymerization in vitro. Kinetic s and morphology studies are monitored using laser light scattering and transmission electron microscope, respectively.
