The Arriaga group applies chemical and engineering principles to design novel strategies to investigate the complexity of biological systems. These strategies respond to one of the most critical challenges faced by modern biomedical, pharmacological, and environmental research, which is the highly heterogeneous nature of cellular architecture, biological function, and response to chemical treatments. The strategies include high-throughput measurements of individual organelles, multi-parametric analysis single cells, subcellular-specific and tissue-specific proteomic and lipidomics, cell engineering, and redox biology, which utilize capillary electrophoresis, HPLC-MS, mass cytometry, molecular biology, and biochemistry resources. Our current projects focus on applications in the fields of aging and its related diseases, metabolic dysfunction, drug response, and cancer.
