Role of Ribonucleotide Reductases in replication and repair; Iron homeostasis and metal cluster assembly in yeast; Mechanism of assembly of the metallo-cofactors required for nucleotide reduction using time resolved physical biochemical methods; Study of clinically active compounds that inactivate reductases and function as antitumor agents; Evolution and regulation of all the enzymes in the Purine Biosynthetic Pathway; Mechanism of DNA cleavers used clinically as antitumor agents; 2D NMR spectroscopy to determine structure of these drugs complexed with the DNA and the structure of the lesioned DNA; Mechanism of repair of the lesions; Mechanism in vivo and in vitro of polyester biosynthesis and homeostasis to generate biodegradable polymers with properites of thermoplastics; rubber biosynthesis.
